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The major active constituents in neem are terpenoids such as azadirachtin, which are considered to be antimicrobial and insect repellant among many other actions, and fatty acids and possibly other compounds in neem oil.15, 16
Traditionally, neem has been administered as roughly 10 to 20 ml (2 to 4 teaspoons) of leaf juice or 2 to 4 grams (1/7 to 1/10 of an ounce) of powdered leaf two or three times per day.17 Leaf extract gel or toothpaste, 1 gram (1/5 of a teaspoon) in the morning and at bedtime brushed all over the mouth, has been used effectively for dental plaque.18 Freeze-dried neem bark extract (30 to 60 mg twice a day) has been shown helpful for people with stomach ulcers.19 Creams containing 5% or more of neem oil or neem extracts are typically applied at least twice per day for skin or vaginal infections. Neem oil (in a concentration of 1 to 4%) mixed in coconut, mustard, or other oil bases is used for repelling insects.20
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