Health: Heart Health Wellness Center
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  • Zestoretic (Lisinopril Hydrochlorothiazide)

    Zestoretic (lisinopril hydrochlorothiazide) is used to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.

  • Lisinopril/Hydrochlorothiazide Oral

    Related Topics

    1. This medicine has multiple active ingredients. Choose an ingredient below to learn more about its interactions.

    2. Hydrochlorothiazide
    3. Lisinopril

    Pronounced

    "lyse-IN-oh-pril/HI-dro-klor-oh-THIGH-uh-zide"

    Common brand names:

    Prinzide, Zestoretic

    Uses

    This medication is used to treat high blood pressure (hypertension). Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This product contains two medications: lisinopril and hydrochlorothiazide. Lisinopril is an ACE inhibitor and works by relaxing blood vessels so that blood can flow more easily. Hydrochlorothiazide is a "water pill" (diuretic) that causes you to make more urine, which helps your body get rid of extra salt and water.

    This product is used when one drug is not controlling your blood pressure. Your doctor may direct you to take the individual medications first, and then switch you to this combination product. Do not continue taking the individual medications (lisinopril and/or hydrochlorothiazide) after you start this medication.

    Other Uses

    This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional.

    This medication may also be used to treat heart failure.

    How to Use This Medication

    Read the Patient Information Leaflet if available from your pharmacist before you start taking this medication and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

    Take this medication by mouth as directed by your doctor, usually once daily in the morning with or without food. If this medication causes you to urinate more frequently, it is best to take it at least 4 hours before your bedtime to prevent having to get up to urinate.

    If you also take certain drugs to lower your cholesterol (bile acid-binding resins such as cholestyramine or colestipol), take lisinopril/hydrochlorothiazide at least 4 hours before or at least 4 to 6 hours after these medications.

    The dosage is based on your medical condition and response to treatment.

    Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick.

    Tell your doctor if your condition does not improve or if it worsens (for example, your blood pressure readings increase).


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  • Heart Health Costs Less at Walmart
    If you’re concerned about your heart, Walmart’s Heart Health Wellness Center is a great place to find savings on heart health essentials and key information about how to maintain a strong heart. Save when you stock up on everyday heart health basics, like vitamins and supplements, or get great prices on heart rate and blood pressure monitors from brands like ReliOn, Omron and Braun. Not sure where to start? Our Heart Health Buying Guide has tons of ideas your heart will love and make it easy to start saving at Walmart.com. You can also read articles about diet and weight management, then support your cardiovascular health with products to help control cholesterol levels and weight – both over the counter and through the Walmart Pharmacy.